91传媒

Director of the Research Center for Medicinal Plants, PhD, Professor Janar Jenis 

Janar Jenis entered the Institute of Chemistry and Chemical Engineering of Xinjiang University in 1994 with a degree in Applied Chemistry, graduated with honors in 1999. From 1999 to 2004, she worked as a teacher at the Xinjiang Chemical Industrial Institute. In 2001-2002 she studied at the University of Foreign Language in Shiyan. Since 2004, she entered the Master's degree program of the 91传媒 Kazakh National University in the specialty "Chemical Technology of organic substances" and graduated with honors in 2006. In 2009, to the KazNU named after 91传媒, majoring in Organometallic chemistry, catalysis and plant chemistry, defended her doctoral dissertation and received a Ph.D. degree.

From 2009 to the present, Janar Jenis has worked as a senior lecturer, acting associate professor, acting professor and professor of the Department of Chemistry and Technology of Organic Substances, Natural Compounds and Polymers of the Faculty of Chemistry and Chemical Technology of 91传媒 Kazakh National University, she has lectured fluently in Kazakh and English on biochemistry, medical chemistry, organic chemistry and chemistry of natural compounds, conducted laboratory classes.

In 2010-2012, she conducted postdoctoral research at Hoshi Pharmaceutical University, Tokyo (Japan). According to the results of scientific research, 5 articles were published in international journals with a high impact factor. 

In 2014, Janar Jenis won a grant from the Chinese Academy of Sciences for foreign researchers and conducted research work at the Xinjiang Physico-Chemical Technical Institute (07.2014-12.2015, grant No.: 2013FFGB0003).    

2016-2018 years Janar Jenis worked as a senior researcher at the South Korean National Gyeongsang University, in the Department of Applied Life Sciences, in the Laboratory of Natural and Organic Complex Research of Professor Ki Hun Park, and also supervised the scientific work of Korean and foreign undergraduates and doctoral students.

In 2017, she took part in the International Talent Exchange Project of the Chinese Academy of Sciences and became a highly qualified scientist, and from 2018 to 2019 she worked as a researcher at the Shanghai Institute of Medicines of the Chinese Academy of Sciences.

In 2019, by order of the rector of the 91传媒 Kazakh National University, the "Research Center for Medicinal Plants" was opened, the director of which was appointed Janar Jenis. Also in 2019, she received the title of "Excellent University Teacher-2019". In 2020, Jenis Janar was awarded the Medal "For Labor Distinction". Janar Jenis is a member of ASP, ASNP, INPST, MNPS. Janar Jenis is the head of 3 Kazakhstani and 5 international projects. In September 2022, under the leadership of Janar Jenis on the basis of the Research Center of Medicinal Plants, a low-tonnage production of products based on plant raw materials has been opened. In 2023, Janar Jenis was awarded the Medal "For Merits in the development of Science of the Republic of Kazakhstan". Janar Jenis has published about 100 scientific papers, including 22 scientific and review articles in international journals with a high impact factor included in the Thomson Reuters and Scopus database. The Hirsch index is 8.     

Shybyray Yergazy, PhD, senior researcher

Nurlybek Aliya Kairatkyzy, Researcher

Aliya Kairatovna Nurlybekova from 2017 to 2020 studied at the doctoral program of the 91传媒 Kazakh National University in the specialty 6D072100 -"Chemical technology of organic substances". From October 2018 to September 2019, she completed a scientific internship at the Shanghai Institute of Medicines of the Chinese Academy of Sciences, Shanghai, China.

Since 2018, Nurlybekova A.K. has been a member of research groups in the projects AP05133199, AP08856717, AP09259567, AP09057982, CAM202002. Since 2019, she has been working as a researcher at the Research Center for Medicinal Plants of 91传媒 Kazakh National University. Since September 2020, she has been working at the Department of Chemistry and Technology of Organic Substances, Natural Compounds and Polymers of the Faculty of Chemistry and Chemical Technology of 91传媒 Kazakh National University. Nurlybekova A.K. have been published about 30 works, including 3 articles in international journals included in the Thomson Reuters and Scopus database, 5 patents, 1 monograph. The Hirsch index is 3.

Amzeyeva Ulpan Mansurkhankyzy, Researcher

PhD doctoral student of 91传媒 Kazakh National University. He works as a researcher at the Research Center of Medicinal Plants of 91传媒 Kazakh National University. Amzeeva U.M. has 20 publications, including 3 articles in international publications, 7 patents and copyrights, 1 monograph. Has international certificates of advanced training: "Innovative Technologies and Biological Methods" Bosphorus University, Turkey, 2015; "Desarollo de formulaciones biotecnologicas de los principales prodyctos de consumomasivo productos de panaderia y lecheagria", Universidad de Cadiz, Espana, 2019.

Ulpan Mansurkhankyzy Amzeeva took part in the implementation of 4 GF, 2 PCF projects.

Participated in grants of JSC "Science Foundation" for the commercialization of the results of research activities on the following topics:

- "Creation of a technological line for the production of pharmaceutical enterosorbents", 2017 – 2019.

- "Creation of a technological line of fundamentally new sorption-bactericidal dressings", 2018-2021.

He is engaged in the synthesis and research of innovative pharmaceutical products, the search and introduction of new excipients of natural origin into the domestic pharmaceutical technology, the pharmaceutical development of new medicines based on domestic natural raw materials.

Minkayeva Ayaulym Azamatkyzy, Researcher

Abdul Bari Shah, PhD, Associate Research Professor

Aizhamal Baiseitova, PhD

Hassan Gamal Osman Osman, PhD

Postdoctoral Research fellow, Department: Medicinal and aromatic plants – natural products unit Desert Research Center, Cairo, Egypt.

National projects:

• J. Jenis. "Chemical ptofile and biological activity of Kazakhstani Artemisia species" AP19676281, Grant financing for scientific and (or) scientific and technical projects for 2023-2025, Ministry of Internal Affairs of the Republic of Kazakhstan, funded by 98900 thousand tenge.

• J. Jenis. DP21681468 "Organization of production and commercialization of immunomodulatory and antiviral supllements from natural raw materials of Kazakhstan", Grant financing of projects commercialization of the results of scientific and (or) scientific and technical activities for 2023-2025, JSC "Science Foundation", financing – 350,000 thousand tenge.

• J. Jenis. CAM202404 "Phytochemical investigation and biological activity of Kazakhstani Artemisia species" international Kazakh-Chinese project, Central Asian Center for Drug Discovery and Development of the Chinese Academy of Sciences, financing 60,000 US dollars (01.09.2024-30.08.2026).

• Key technology for the active processing of medicinal and edible plants and the development and demonstration of functional products: China-Kazakhstan 5297102D Cooperation, International Scientific and Technical Cooperation of Hebei Province, China, with the College of Food Sciences and Biology of Hebei University of Science and Technology, China, 50,000 RMB, 2025-2027.

International projects:

1. Jenis J. Cooperation on the study and development and industrialization of traditional medicine, which was adopted and sponsored by the international cooperation project of the Chinese Academy of Sciences (GJHZ1678, 2016-2020). 

2. Jenis J. «Phytochemical profile and biological activity of medicinal plants of Kazakhstan» international Kazakh-Chinese project, Central Asian Center for Drug Discovery and Development of the Chinese Academy of Sciences, financing 100,000 US dollars (01.07.2020-30.06.2022).  

3. Jenis J. «Research on the collection, identification and processing technology of medicinal resources of Medicinal plants from China and Kazakhstan, and analysis of corresponding processing characteristics of drying» International Kazakh-Chinese project, Institute of Storage and Processing of Agricultural Products of the Academy of Agricultural Sciences of the People's Republic of China, equipment financing in the amount of 13,000 thousand tenge (2021-2023).

4. Jenis J. «Potential Botanical Formula against Influenza Virus», International Joint Center program of Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project (2021-2024).

5. Jenis J. «Research on the Application of Supercritical Carbon Dioxide Extraction Instrument for Bulk Spices Plant Resources in Central Asia» International Kazakh-Chinese project, Institute of Storage and Processing of Agricultural Products of the Academy of Agricultural Sciences of the People's Republic of China, financing 3,250 thousand tenge (2022-2024).

Based on the research results, experimental batches of biologically active additives were released:

1. Antiviral;

2. To maintain immunity;

3. To maintain women's health;

4. To maintain the liver.

In addition, herbal teas have been developed in order to:

• Maintaining immunity;

• Lowering blood sugar levels in diabetes;

• Blood pressure regulation;

• Improvement of the gastrointestinal system.

The State registration of the biologically active additive TKM-Immuno has been carried out. A Declaration of conmfority for the Tea mixture TKM-Natural Tea was received. Work on state registration and declaration of conformity of products continues.

The Research Center for Medicinal Plants of the 91传媒 Kazakh National University and low-tonnage production also gained publicity in the media:

1. Farabi Media: "KazNU-da zhana ondiris iske kosyldy"  

2. Egemen Qazaqstan: "Coronavirus karsy tunba – kop aurudyn emi"

3. DKN World News: "A workshop for the production of medicines has opened in KazNU"

4. Jas Qazaq: "Janar Jenis, Professor: Almatydagy zhastardyn gylymga kyzygushylygy artyp keledi"  

5. El.kz : "Arshamen, adyraspanmen alastau – myth emes, umytylyp ketken gylym"

6. Qazaqstan TV channel: Tansholpan bagdarlamasy: "Bugin – gylym kyzmetkerleri kuni: Kazak Ulttyk universitetinde zhusannyn paidasy zerttelip zhatyr" 

7. Azattyq Ruhy: "Elimizde zhas galymdar zhusan shobinen diabetke karsi dari azirlep zhatyr"

8. Kazinform International News Agency: "Kazak galymy zertteu zhumysyn AKSh-ta zhalgastyrady"

9. Qazaq1913: Janar Jenis: "Biz shygargan antivirusty tabigi kospaga suranis kop"  

Business trips within the framework of the Center's activities:

1. Business trip to Mississippi University, Oxford, Mississippi, USA (KazNU scientist's research will continue in the USA // MIA "DKNews", 11/21/2022, ,
2. "Eighth International Mediterranean Symposium on Medicinal and Aromatic Plants (MESMAP-8)" in Selcuk, Izmir, Turkey (October 20-22, 2022)
3. 10th International Conference on Science, Technology, Engineering and Mathematics // Phytochemical and pharmacological studies of medicinal plants of Kazakhstan, Zhenis Zhana. September 24, 2022, Malaysia.
4. Joint research with Nazarbayev University, Astana, Kazakhstan
5. The International Symposium "KSABC International Symposium 2023" in Jeju, Korea, 06/18/2023. ,
6. Conference "On the establishment of the Professional Committee on Ethnic Medicine of the Chinese Pharmaceutical Association and the 60th anniversary of the Xinjiang Pharmaceutical Association", 11.07.2023  
7. Cooperation with Tianjin Institute of Industrial Biotechnology (TIB), Chinese Academy of Sciences, China, 2023
8. 23rd China International Industrial Exhibition 2023, Shanghai, China, September 19-23, 2023 https://www.ciif-expo.com/, https://
9. Expeditions to collect plant raw materials in 2021-2023 under the project (North Kazakhstan Region, South Kazakhstan Region, East Kazakhstan Region and Almaty region, Kazakhstan)

The Center provides training for young scientists: high school students of the specialized Lyceum No. 92 named after M. Gandhi, undergraduate students, undergraduates and domestic and foreign doctoral students.

Brief description of the project AP09259567 "Multi-botanical Oral Supplement to Suppress the Spreading of SARS in Humans"

The strategic policy of the Republic of Kazakhstan is aimed at creating high-tech technologies based on pharmaceutical production by reducing planned dependence on imported medicines, i.e. domestic production forces, raw materials, the scientific and technical potential of the country and high-tech technologies. Today, one of the main directions of development of the Republic of Kazakhstan is the development of the pharmaceutical industry at the expense of domestic raw materials. More than 7,000 medicines have been registered in the State register of the Republic of Kazakhstan. The share of domestic drugs is 30 %, in value-10 %, respectively, 90 % of pharmaceutical products are met by the demand for imported drugs. Providing the pharmaceutical market with new medicines of domestic production in the conditions of import dependence in the country is an important stage in the process of formation of the pharmaceutical industry in Kazakhstan. In this case, it is important to study the development potential of domestic pharmaceutical products by studying the production of a new lead natural product using a wide range of medicinal plants in Kazakhstan.

A number of coronavirus outbreaks have struck the world in recent times (MERS-CoV, SARA-CoV, and SARS-CoV-2) and that it would be reasonable to predict that future outbreaks will occur. Medicinal plants have been the source of various medical product leads in drug discovery. It is not a surprise that plant products and their analogues have could be employed as an early line of defence against SARS. It would be valuable to have botanical preparations that could help prevent/build resilience to future respiratory viral infection outbreaks. The main role of these preparations is to suppress SARS-CoV-2 cell entry through targeting transmembrane protease serine 2 (TMPRSS2) and block coronavirus replication via targeting the viral 3-chymotrypsin-like cysteine protease (3CLpro). Hoffmann et al., (Cell 181 2020) has shown that SARS-CoV-2 cell entry depends on angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). Targeting ACE2 will present some challenge as it has a beneficial role in many diseases such as hypertension, diabetes, and cardiovascular disease, so targeting TMPRSS2 will become more visible. Medicinal plants have been the source of various medical product leads in drug discovery. It is not a surprise that plant products and their analogues have could be employed as an early line of defence against influenza virus. Several plants are known to possess potential potency towards TMPRSS2 such as; Scutellaria baicalensis, Aloe vera, and Hydrocotyle leucocephala. The edible Hydrocotyle leucocephala that contains hinokinin which has been shown to potentially inhibit TMPRSS2 (RSC Advances 10 (2020).

The use of nutraceutical formula with potent established activity against such types of viruses in a combination of immune-boosting botanical seems to be the quickest approach making benefit of the wealth of information that is already known. The present project for natural drug research from medicinal and edible plant resources will be engaged in cutting edge fundamental and translational research on phytochemical compositions to develop safe and effective phytomedicines of defence against viral influenza, SARS and future human health threatened pandemics. Similar to TMPRSS2 approach, we will confirm the activity of several 3CLpro known active plants in our research center to select the most suitable candidate. Our attempt is to establish the potent and safe botanical formula of fifteen different medicinal and edible plants (1-15). And this recipe has long been used as a Traditional Kazakh Medicinal (TKM) remedy against influenza, inflammation and various viral infections. We have expanded and improved the recipe based on the latest research from other plants. Thus, we present this recipe as a meaningful and advanced effective remedy. Moreover, the multi-botanical formula is being registered at «The Committee for Sanitary and Epidemiological Control of the Ministry of Health of the Republic of Kazakhstan» as an oral supplement in granule form.

The goal research project mainly focused on using sevral selected bioactive medicinal and edible plants, to generated new antiviral botanical oral supplement, determinate its chemical constituents, isolation of the main natural product leads, study their structure and pharmacological activities, run in vitro screening towards TMPRSS2 and 3CLpro to develop new methods and techniques to create natural, safe multi-botanical preparation to suppress the spreading of SARS in humans.

The developed product. Within the framework of the project, a botanical formula was developed, consisting of fifteen types of medicinal and nutritious herbal supplements that have a powerful effect against coronavirus. The main role of these drugs is to suppress the penetration of SARS-CoV-2 cells through targeting transmembrane serine protease 2 (TMPRSS2) and blocking the replication of coronavirus through targeting viral 3-chymotrypsin-like cysteine protease (3CLpro). For the first time, a multi-botanical oral supplement was created that has preventive and curative properties with a main focus on the influenza virus, SARS in Kazakhstan. A safe product from medicinal and edible plants has been created that provides short-term access to the influenza virus and SARS to patients. This formula guarantees its function through two main dual mechanisms, including the inhibition of coronaviruses and the enhancement of the immune system (袣芯褉芯薪邪胁懈褉褍褋覜邪 覜邪褉褋褘 褌冶薪斜邪 – 泻萤锌 邪褍褉褍写褘遥 械屑褨 // Egemen Qazaqstan, 06.03.2023, ).

The economic point realization of the project will highlight the new biologically active natural leads needed to obtain drugs with a further introduction to medicine and will contribute to accelerated innovation development of the economy of the Republic of Kazakhstan.

Social effect. The developed technology will open new businesses and jobs, improve profitability and the economic effect of existing enterprises. Young Scientists participation in the project will allow improving the quality of education and training of highly qualified specialists that in the future will increase their ability for a better career development.

The research is carried out at the Research Center for Medicinal Plants (/science/nii/51) On the basis of the Research Center for Medicinal Plants of the 91传媒 Kazakh National University, a low-tonnage production of innovative products based on plant raw materials was opened (覛邪蟹野校-写邪 卸邪遥邪 萤薪写褨褉褨褋 褨褋泻械 覜芯褋褘谢写褘 // Farabi Media – KazNU, 12.09.2022, ). Experimental batches of biologically active supplements have been released: antiviral, immunomodulatory, for women's health, and for liver protection. Herbal teas are produced in order to regulate blood pressure; reduce blood sugar levels in diabetes; maintain immunity; maintain the full functioning of the stomach. Work is underway on state registration and declaration of conformity of products.     

Collaborations under the frame of the projects: Nazarbayev University, Astana, Kazakhstan; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA; Division of Applied Life Science (BK21 four), IALS, Gyeongsang National University, Jinju 52828, Republic of Korea, Tianjin Institute of Industrial Biotechnology (TIB), Chinese Academy of Sciences (CAS), and Xinjiang Technical Institute of Physics and Chemistry , CAS.

Based on the project, the Plant expeditions (2021-2023) were carried out with all members of the research team (North, South, East , and Almaty region of Kazakhstan). Based on the project trained young scientists: High school students, Bachelor, Master and PhD students.

Based to the obtained results from present project, our team has been submitted 2 articles in journals which recommended by CQA (Committee for Quality Assurance, Ministry of Education and Science of Republic Kazakhstan) of which, 2 articles in a peer-reviewed scientific journals, meanwhile presented 13 paper presentations at national and international conferences and submitted one patent applications in the Republic Kazakhstan (RK). Moreover, the multi-botanical formula has been tested by accredited laboratory of "NUTRITEST" LLP (No. 23P dated 02/23/2022 for Biologically active additive "TKM-Immuno"), and passed through the expert evaluation of materials for Biologically active additive "TKM-Immuno", LLP "OO Kazakh Academy of Nutrition" (No. 19/EC-105-22 dated 30.03.2022). Successfully the oral supplement has been registered at «The Committee for Sanitary and Epidemiological Control of the Ministry of Health of the Republic of Kazakhstan» as an oral supplement in granule form («TKM-Immuno» KZ.16.01.98.003.R.000318.06.22, 17.06.2022).

Publications within the project:

Abstracts:

1. Minkayeva A.A., Mohamed Ali Ibrahim, J.Jenis. Studying the chemical composition and biological active constituents of the Ferula Foetida // Republican scientific and practical conference with the participation of foreign scientists “Prospects and development of chemistry of natural compounds in Uzbekistan", May 27, 2021, Tashkent, Uzbekistan.

2. Minkayeva A.A., Nurlybekova A.K., Kudaibergen A.A., Zharkyn Zh., Jenis J. Chemical Constituents of the Prunus Armeniaca, Ficus Carica and Vitis Vinifera // The XI International Beremzhanov Congress on Chemistry and Chemical Technology, 19-20 November, 2021, Almaty, Kazakhstan;

3. Aitugan R.N., Nurlybekova A.K., Karl Zh. M, Kudaibergen A.A., Dusebayeva M.A., Jenis J. Chemical Constituents of the Dianthus superbus, Matricaria chamomilla and Glycyrrhiza glabra // The XI International Beremzhanov Congress on Chemistry and Chemical Technology, 19-20 November, 2021, Almaty, Kazakhstan;

4. Aitugan R. N., Jenis J.comparative study of the chemical composition of the Glycyrrhiza glabra plant collected from different regions of Kazakhstan / / Abstracts of the report of the International Conference of students and young scientists "Farabi Alemi", NAO " 91传媒 Kazakh National University", April 6-8, 2022 Almaty, Kazakhstan.

5. Jenis J. Phytochemical and pharmacological studies of medicinal plants from Kazakhstan // 8th International Mediterranean Symposium on Medicinal and Aromatic Plants October 20-22, 2022 / Selcuk, Izmir – Turkey.

6. Minkaeva A., Kudaibergen A., Amzeeva U., Jenis J. Studying the chemical composition and biological active constituents of the Ferula foetida // 8th International Mediterranean Symposium on Medicinal and Aromatic Plants October 20-22, 2022 / Selcuk, Izmir – Turkey.

7. Aiya Sovetbek, Ayaulym Minkayeva, Aliya Nurlybekova, Janar Jenis. Chemical constituents of the aerial part of the Ferula foetida // International Scientific Conference "Actual Problems of the Chemistry of Natural Compounds", March 15-16, 2023, Tashkent, Uzbekistan  

8. Ayaulym Minkayeva, Aiya Sovetbek, Aidana Kudaibergen, Ulpan Amzeyeva, Jenis Janar. Studying the Chemical Composition and Biological Active Constituents of the Ferula Foetida’s Underground Part // International Scientific Conference "Actual Problems of the Chemistry of Natural Compounds", March 15-16, 2023, Tashkent, Uzbekistan.  

9. Aliya Nurlybekova, Yang Ye, Janar Jenis. Phytochemical Profile and Biological Activities of Ligularia narynensis // The 9th International Mediterranean Symposium on Medical and Aromatic Plants, May 03-05, 2023 Ankara, Turkey.

10. Ulpan Amzeyeva, Aliya Nurlybekova, Aydana Kudaibergen, Shyngys Mamashev, Janar Jenis. Chemical Constituents of Dianthus superbus, Matricaria chamomilla and Glycyrrhiza glabra // The 9th International Mediterranean Symposium on Medical and Aromatic Plants, May 03-05, 2023 Ankara, Turkey.

11. J. Jenis. Phytochemical profiles and biological activities of endemic medicinal plants from Kazakhstan // International Scientific and Technical Conference Actual Problems of the Chemistry of Natural Compounds, March 15- 16, 2023, Tashkent.   

12. J. Jenis Investigation Bioactive Natural Product from Medicinal Plant of Kazakhstan. // KSABC International Symposium 2023, June 18-20, 2023 Jeju, Korea.

The following articles have been submitted to journals included in the Scopus and/or Web of Science databases:

1. Aknur Taldybay, Doktorhan Aydarbayeva, Akhmet Aksoy, Gulnara Sitpayeva, Alfyia Kurmantayeva, Mohamed A. Ibrahim, Aizhamal Baiseitova, and Janar Jenis. Resources, Morphological, Anatomical Characterization, Phytochemical Profiles and Pharmacological Properties of Ajania fastigiata (C. Winkl.) Poljakov // Saudi Journal of Biological Sciences, Submitted 09. 2023 (Percentile 89, Q1).

2. Janar Jenis, Aizhamal Baiseitova, Zhanna Akzhigitova, Ulpan Amzeyeva, Akbota Kurmangaliya, Gulsim Kulsharova, Mohamed A. Ibrahim, Jeong Yoon Kim. Multi-botanical Oral Supplement to Suppress the Spreading of SARS: Phytochemical Profile and Pharmacological Activities // Frontiers in Pharmacology, Submitted 09.2023 (Percentile 79, Q1).

3.Aliya Nurlybekova, Ayaulim Minkayeva, Yergazy Shybyray, Chun-Ping Tang, Chang-Qiang Ke, Sheng Yao, Yang Ye and Janar Jenis. Phytochemical Constituents and Their Cytotoxic and Antiinflammation Activities of Ligularia narynensis // Molecules, ready to submit in 10.2023 (Percentile 78, Q2).

Articles have been submitted in a journal recommended by the Committee for Quality Assurance in Education and Science of the Ministry of Science and Higher  Education of the Republic of Kazakhstan:

1. A.A. Minkayeva, Sh.M. Mamashev, A.K. Nurlybekova, A.A. Kudaibergen, Ye. Shybyray, U. Amzeyeva, J. Jenis. Chemical Constituents of Dianthus superbus, Matricaria chamomilla and Glycyrrhiza glabra // International Journal of Biology and Chemistry, 2023.

2. A.A. Sovetbek, A.A. Minkayeva, A.K. Nurlybekova, J. Jenis. Comparative Study on Phytochemical Constituents of Aerial and Underground Parts of Ferula foetida from Kazakhstan // Pharmacy of Kazakhstan, 2023

International cooperation

•  Xinjiang Technical Institute of Physics and Chemistry, CAS, China;

• Shanghai institute of Materia Medica, CAS, China;

• The Institute of the Chemistry of Plant Substance, Academy of Sciences of Uzbekistan (ICPS);

• Gyeongsang National University, Korea;

• Griffith Institute for Drug Discovery, Griffith University, Brisbane, Australia;

• Kunming Institute of Zoology, CAS, China;

• College of Life Sciences, University of CAS, China;

• Research Institute of Pharmaceutical Sciences, University of Mississippi, USA;

• School of Chemical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia;

• Universiti Pendidikan Sultan Idris, Tanjong Malim, Perak Darul Ridzuan, Malaysia;

• Technical Institute of Physical and Chemistry, CAS, China.

The main publications in the database Scopus, Pubmed, zbMATH, MathSciNet, Agris, Georef, Astrophysical journal:  

1                  Janar Jenis, Ayaulym Minkayeva, Orynkul Yessimova, Saltanat Kumargaliyeva, Abdul Bari Shah, Thiruventhan Karunakaran, Kuzembekova Gulnur, Haji Akber Aisa*, Aizhamal Baiseitova. Comparative Phytochemical, Colloidal, and Antioxidant Profiling of Artemisia albida, Artemisia leucodes, and Artemisia scopaeformis: Potentials for Cosmeceutical and Nutraceutical Applications // Molecules 2025, 30(21), 4165; Q1, Percentile 82

2                  Saiya Hou , Wanlu Liu, Qiaoli Zhang, He Li, Zhao Guo, Janar Jenis, Xinqi Liu. The multi-target mechanism of food derived peptides in improving knee cartilage injury: anti-inflammatory effects, matrix metabolism regulation, and oxidative stress protection // Food Bioscience 74 (2025) 107901, Q1

3                  Abdul Bari Shah, Aizhamal Baiseitova, Ulpan Amzeyeva, Xiaofei Shang and Janar Jenis. α-Glucosidase Inhibition-Guided Network Pharmacology and Molecular Docking Reveal the Antidiabetic Potential of Cichorium intybus as a Functional Food // International Journal of Molecular Science 2025, 26, 9497, https://doi.org/10.3390/ijms26199497, Q1, Percentile 90

4                  Aizhamal Baiseitova, Ulpan Amzeyeva, Aiya Tolepbergen, Yasmina Ulfanova, Yergazy Shybyray, Lixia Dai, Xiaofei Shang, Abdul Bari Shah, Jeong Yoon Kim, Janar Jenis. Response Surface Methodology Optimization on Ultrasonic鈥�Assisted Extraction of Chicory (Cichorium intybus L.) and Their UPLC鈥�ESI鈥�QTOF鈥�MS Analysis, Antioxidant and Hepatoprotective Activity // eFood, 2025; 6:e70081 eFood Q1, Percentile 72

5                  Shybyray, Yergazy, Liu, Liu, Kaiyrkulova, Aida, Huang, Xinge, Jenis, Janar, Li, Jun, Aisa, Haji Akber. LC-MS/MS-Guided Discovery of Sinapic Acid Derivatives from Lepidium sativum Seeds and Their Anti-inflammatory Activity // Journal of Agricultural and Food Chemistry, 2025, DOI: 10.1021/acs.jafc.5c03622. Q1, Percentile 94

6                  He, Xuebing, Sun, Mingna, Battulga, Tungalag, Copp, Brent R., Rustamovna, Dilobarkhon Kodirova, Li, Hongyan, Shahsaidovich, Sagdullaev Shamansur, Shahsaidovich S.S., Jenis, Janar, Wang, Yuqing, Wang Y., Liang, Lu. Application of Artificial Intelligence in the Development of Traditional Chinese Medicine // Basic and Clinical Pharmacology and Toxicology, 2025, DOI: 10.1111/bcpt.70066. Q2, Percentile 66

7                  Ayaulym Minkayeva, Saltanat Kumargaliyeva, Orynkul Yessimova, Yasmina Ulfanova, Shang Xiaofei, Aizhamal Baiseitova, Janar Jenis. Phytochemical and colloidal analysis of Artemisia hydrolates and their activities against low-density lipoprotein oxidation // Heliyon, 11, 2025, 42677, Q1, Percentile 82

8                  Shybyray Y., Zou G.A., Jenis J., Aisa H.A., Li J. Constituents of Lepidium sativum // Chemistry of Natural Compounds, 61, 2025, 199-201, DOI 10.1007/s10600-025-04612-7, Q4, Percentile 30

9                  Ziwei Zhu, Ablajan Turak, Nannan Xu, Janar Jenis, Haji Akber Aisa. Three new monoterpenes compounds isolated from Seriphidium terrae-albae exerted anti-inflammatory effects through the JAK/STAT and NF-κB signaling pathways // Fitoterapia, Accepted date: 4 December 2024. https://doi.org/10.1016/j.fitote.2024.106335 Q3, Percentile 58

10              Shybyray, Yergazy; Kaiyrkulova, Aida; Zhao, Hai-Qing; Jenis, Janar; Aisa, Haji Akber; Li, Jun. Isolation of Novel Compounds from Lepidium sativum // Chemistry and Biodiversity, 22, 2025, 202402071, Q3, Percentile 49

11              Jegathiswary Ganasan, Thiruventhan Karunakaran, Yathindra Marimuthu, Nurul Najwa Rusmadi, Noor Syarafana Firouz, Janar Jenis, U. Seeta Uthaya Kumar. Chemistry and toxicity of 7-hydroxymitragynine (7-OHMG): an updated review on the oxidized derivative of mitragynine // Phytochemistry Reviews, Accepted: 25 September 2024, . Q1, 锌褉芯褑械薪褌懈谢褜 97

12              Xiaorong Yang, Xiaolou Miao, Lixia Dai, Xiao Guo, Janar Jenis, Jiyu Zhang and Xiaofei Shang. Isolation, biological activity, and synthesis of isoquinoline alkaloids // Natural Product Reports, Received 21st May 2024, Q1, Percentile  97

13              Dandan Zhao, Zhuofan Ji, Yukun Xia, Huan Rao, Zhentao Zhang, Janar Jenis,  Jianxiong Hao. Effects of different pretreatment on the drying characteristics and pectin properties of jujube by microwave coupled with pulsed vacuum drying // Journal of Food Process Engineering 2024; 47:e14674. Q2, Percentile  73

14              Xiaorong Yang, Lixia Dai, Fengyuan Yan, Yudong Ma, Xiao Guo, Janar Jenis, Yu Wang, Jiyu Zhang, Xiaolou Miao, Xiaofei Shang. The phytochemistry and pharmacology of three Rheum species: A comprehensive review with future perspectives // Phytomedicine 131 (2024) 155772. Q1, Percentile  97

15              Taldybay, Aknur; Aidarbayeva, Doktorkhan; Aksoy, Ahmet; Sitpayeva, Gulnara; Baiseitova, Aizhamal; Jenis, Janar. Ajania fastigiata in Zhetysu Alatau: Distribution, morphological characterization, phytochemical profiles, and optimization of extraction of bioactive constituents // Journal of Applied Research on Medicinal and Aromatic Plants, 2024, 40, 100540. Q1, Percentile  85

16              Zhu, Dafu; Yuan, Jie; Yue, Quanqi; Zhao, Yinggong; Yu, Shan; Zhamilya, Abilova; Jenis, Janar; Tang, Chunping; Wang, Bo; Liu, Jia; Ye, Yang. Building Block Extractor: An MS/MS Data Mining Tool for Targeted Discovery of Natural Products with Specified Features // Analytical Chemistry, 2024, 95 (29), 10939. Q1, Percentile 91.

17              Peng Xu, Zhentao Zhang, Xueyuan Peng, Junling Yang, Xiaoqiong Li, Tiejian Yuan, Xiaohan Jia, YaoyangLiu, Olim Abdullaev, Janar Jenis. Study on vacuum drying kinetics and processing of the Lonicera japonica Thunb. aqueous extracts // LWT - Food Science and Technology 2022, 167, 113868. Q1, Percentile  94

18              Sailike B., Omarova Zh., Jenis J., Adilbayev A., Akbay B., Askarova S., WeiLin Jin, Tokay T. Neuroprotective and Anti-Epileptic Potentials of Genus Artemisia L. // Frontiers in Pharmacology, 13,1021501. Q1, Percentile  85

19              Nurlybekova A.K., Kudaibergen A.A., Kazymbetova A., Amangeldi M., Baiseitova A., Ospanov M., Haji Akber Aisa, Yang Ye, Mohamed Ali Ibrahim, Jenis J. Traditional Use, Phytochemical Profiles and Pharmacological Properties of Artemisia Genus from Central Asia // Molecules 2022, 27, 5128. Q2, Percentile  83

20              KazymbetovaA., Amangeldi M., Nurlybekova A.K., Amzeyeva U., Baktybala K., Chung-Ping Tang, Chang-Qiang Ke, Sheng Yao, Yang Ye, Jenis J.  Secondary Metabolites and Their Cytotoxic Activity of Artemisia nitrosa Weber.and Artemisia marschalliana Spreng // Molecules 2022, 27 (22), 8074. Q2, Percentile  83

21              Ospanov M., Leon F., Jenis J., Khan IKhlas A., Ibrahim M.A., Challenges and future directions of potential natural products leads against 2019-nCoV outbreak // Current Plant Biology - 2020. Q1, Percentile 95

22              Akzhigitova Z., Dyusebaeva M.A., Tokay T., Lijiang X., Jenis J.  Phytochemical Study of Bergenia crassifolia // Chemistry of Natural Compounds, 2020, 56(5), 褋. 912-914. Q4, Percentile 28

23              Janar Jenis, Aizhamal Baiseitova, Sang Hwa Yoon, Chanin Park, Jeong Yoon Kim, Zuo Peng Li, Keun Woo Lee, Ki Hun Park. Competitive a-glucosidase inhibitors, dihydrobenzoxanthones, from the barks of Artocarpus elasticus // Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34 (1): 1623–1632. Q1, Percentile 90

24              Abilova Zh., Yaun J., Jenis J., Tang Ch., Ye Y. Monomeric and Dimeric Sesquiterpene Lactones from Artemisia heptapotamica // Chinese Journal of Natural Medicines, 2019, 17 (10): 785-791. Q1, Percentile  90

25              Zhu, Nanlin; Tang, Chunping; Xu, Cheng-Hui; Ke, Chang-Qiang; Lin, Ge; Jenis, Janar; Yao, Sheng; Liu, Hongchun; Ye, Yang. Cytotoxic Germacrane-type Sesquiterpene Lactones from the Whole Plant of Carpesium lipskyi // Journal of Natural Products, 2019, 82(4): 919-927. DOI: Q1, Percentile  93  

26              Aizhamal Baiseitova, Janar Jenis, Jeong Yoon Kim, Zuo Peng Li and Ki Hun Park.    Phytochemical analysis of aerial part of Ikonnikovia kaufmanniana and their protection of DNA damage // Natural product research, 2019, 14: 1-4. Q3, Percentile  78

27              Ji Yeong Kim, Jeong Yoon Kim, Janar Jenis, Zuo Peng Li, Yeong Jun Ban, Aizhamal Baiseitova, Ki Hun Park. Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle) // Bioorganic & Medicinal Chemistry, 2019, 27(12): 2499-2507. . Q1, Percentile  75

Books:

1. J. Jenis, Nurlybekova A.K., Akzhigitova Zh.Zh. Phytochemical composition and biological activity of Artemisia species from Kazakhstan. Monograph / J. Jenis, A. K. Nurlybekova, Zh. Zh.Akzhigitova.  – Almaty: Kazakh University, 2022. - 182 p. (in Russian). ISBN 978-601-04-6100-0.  

2. J. Jenis. Medicinal plants, phytochemicals, biological activity // Publishing House of Kazakh National University, 2020, 160 pages (in Kazakh).

3. J. Jenis. Bioactive Natural Products from Medicinal Plants // Publishing House of Kazakh National University, 2020, 160 pages (in English).

4. Chemistry of natural compounds: an educational and methodical manual / J. Jenis, – Almaty: Kazak University, 2020. – 208 P. (in Russian, Kazakh, English).

 Patents of the Republic of Kazakhstan:

1. Patent for the invention "Method of obtaining a biologically active complex with antidiabetic action", applicant DGP Scientific Research of new chemical technologies and materials; No. 34841, application 10.10.18g. Haji Akbar Aisa, Dyusebaeva M.A., Nurlybekova A.K., Jenis J.

2. Patent for a useful model "A method for producing antioxidant agent", applicant Jenis J.; No. 5792, application 19.10.2020 Jenis J., Dyusebaeva M.A., Bayseitova A., Nurlybekova A.K., Kudaibergen A.A.  

3. Patent for a useful model "A method for producing a vasorelaxant agents", applicant Jenis J.; No. 5835, application 23.10.2020 Jenis J., Dyusebaeva M.A., Nurlybekova A.K., Kudaibergen A.A.

4. Patent for a useful model "Method for obtaining an antidiabetic active complex", applicant Jenis J.; No. 5963, application. 19.01.2021 Jenis J., Bayseitova A., Hadji Akbar Aisa, Dyusebayeva M.A., Nurlybekova A.K.

5. Patent for a useful model "Way of developing virus-inhibiting agent of plant origin", applicant Jenis J.; No. 7367, application 04.07.2022, 19.08.2022, Jenis J., Nurlybekova A.K.